Cocaethylene


A Comprehensive Guide to Cocaethylene Drug Testing

Introduction to Cocaethylene

Cocaethylene is a chemical compound formed in the body when cocaine and alcohol are consumed together. This unique substance results from the liver metabolising both substances simultaneously, creating a more potent and longer-lasting euphoric effect than cocaine alone. However, it also increases the risk of toxic effects, including cardiovascular complications and liver damage.

Street Names

Cocaethylene Street Names

While cocaethylene itself does not have street names, it forms in the body when the following substances are mixed:

  • Cocaine: Coke, Blow, Snow, Crack
  • Cocaine metabolite 

 

Cocaethylene's Chemical Structure

Cocaethylene is an ethyl ester of benzoylecgonine, the primary metabolite of cocaine. Its chemical formula is C18H23NO4, and its structure is similar to cocaine, allowing it to bind more strongly to dopamine transporters, which contributes to its enhanced euphoric effects and increased toxicity.

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Cocaethylene

How To Test For Cocaethylene

Here are the most common tests used to detect cocaethylene and their detection windows:

 

01

Hair

Long Detection Window (Months)

Hair

Hair testing can detect cocaethylene use for several months or more, depending on the length of the hair sample.

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03

Urine

Medium Detection Window (Days)

Urine

Cocaethylene can generally be detected in urine for up to 72 hours after use.

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04

Blood

Short Detection Window (Hours to Days)

Blood

Blood tests can identify cocaethylene for a short duration after use, typically up to 24 hours.

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05

Saliva

Short Detection Window (Hours to Days)

Saliva

Saliva tests can detect cocaethylene shortly after ingestion, though the detection window is brief (hours).

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Legitimate Use Cases for Cocaethylene

Legitimate Use Cases for Cocaethylene

Cocaethylene is not an active compound of cocaine and  is not associated with any legitimate medical or therapeutic use. Its presence in the body occurs exclusively as a byproduct of using cocaine and alcohol together, making it an indicator of substance misuse.

 

Will Cocaethylene Show Up on a Drug Test?

Will Cocaethylene Show Up on a Drug Test?

Yes, cocaethylene can be detected in specialised drug tests designed to identify this metabolite. However, routine drug screenings do not typically test for cocaethylene unless there is a specific need to investigate concurrent cocaine and alcohol use.

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How Long Does Cocaethylene Stay in Your System?

Cocaethylene’s presence in the body depends on factors like the quantity of cocaine and alcohol consumed and individual metabolic rates. On average, it remains detectable for:

  • Urine: 1 to 3 days
  • Hair: several months
  • Blood: Up to 1 day
  • Saliva: A few hours

 

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Factors Influencing Cocaethylene’s Presence in Your Body

The following factors can affect how long cocaethylene stays in your system:

  • Amount Consumed: Larger quantities of cocaine and alcohol lead to higher levels of cocaethylene.
  • Metabolism: Individuals with faster metabolic rates may process cocaethylene more quickly.
  • Frequency of Use: Chronic or repeated use can extend the detection window.
  • Health Conditions: Liver health significantly influences the formation and breakdown of cocaethylene.

 

Cocaethylene Use in Legal Scenarios

Cocaethylene Use in Legal Scenarios

The detection of cocaethylene is particularly relevant in legal contexts such as:

  • Legal & DUI/DWI Cases: Evidence of concurrent cocaine and alcohol use can aggravate charges.
  • Probation Drug Testing: Cocaethylene detection can indicate non-compliance with substance use restrictions.
  • Accident Investigations: Cocaethylene is often tested in forensic toxicology to assess impairment or substance misuse.

 

False Positives and Interpretation of Cocaethylene Results

False positives for cocaethylene are rare, as it is a specific metabolite formed only when cocaine and alcohol are present. Confirmatory testing (e.g., Gas Chromatography-Mass Spectrometry, or GC-MS) is used to ensure accuracy.

 

Cocaethylene Use in Legal Scenarios
Popular Culture and Cocaethylene

Popular Culture and Cocaethylene

Cocaethylene is not widely discussed in popular culture. However, its dangers underscore the risks of mixing cocaine and alcohol, a behaviour sometimes glamorised in certain subcultures.

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Popular Culture and Cocaethylene

Notable Forensic Cases Involving Cocaethylene

Cocaethylene has appeared in forensic cases where fatalities occurred due to cocaine and alcohol use. Its detection has provided critical evidence in investigations involving overdoses, impaired driving incidents, and violent crimes linked to substance abuse.


 

Risk of Contamination

Since cocaethylene is mainly formed within the body, contamination risks in testing are minimal. However, proper handling and storage of biological samples are essential to ensure the accuracy of test results

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